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[Renal excretion of phosphates in humans during the various phases of growth]

O Losana1, M Messina, G Anselmo

  • 1Istituto di Clinica Medica Generale dell'Università di Torino.

Archivio Per Le Scienze Mediche
|September 1, 1969
PubMed

Insights

Human Growth Hormone (HGH) increases blood phosphorus and tubular reabsorption in children and adolescents aged 3-19. These effects are most pronounced between ages 6-13 and diminish after 14.

Area of Science:

  • Pediatric Endocrinology
  • Human Physiology
  • Biochemistry

Context:

  • Investigating the physiological changes in mineral metabolism during childhood and adolescence.
  • Understanding the role of hormones in regulating blood phosphorus levels.
  • Establishing reference ranges for phosphorus and its tubular reabsorption in pediatric populations.

Purpose:

  • To compare blood phosphorus and Tubular Reabsorption of Phosphorus (TRP) values between children/adolescents and adults.
  • To determine the age-specific patterns of phosphorus metabolism in individuals aged 3 to 19 years.
  • To investigate the potential influence of Human Growth Hormone (HGH) on these parameters.

Summary:

  • Blood phosphorus and TRP were measured in 54 subjects (3-19 years) and compared to 39 adults.
  • Children and adolescents exhibited significantly higher blood phosphorus and TRP values compared to adults.
  • These increases were most notable in the 6-13 year age group, gradually decreasing after age 14, and are attributed to HGH action.

Impact:

  • Provides insights into the hormonal regulation of phosphorus metabolism during growth and development.
  • Highlights age-related variations in renal phosphorus handling.
  • Suggests a significant role for HGH in modulating phosphorus balance in pediatric populations.

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