Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral regeneration.

Zu-Lin Chen1, Wei-Ming Yu, Sidney Strickland

  • 1Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, NY 10021, USA. chenz@rockefeller.edu

Annual Review of Neuroscience
|March 8, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[The research progress and outlook on the effects of different exercise modalities on working memory function in middle-aged and elderly individuals].

Sheng li xue bao : [Acta physiologica Sinica]·2026
Same author

Beyond Fibrinolysis: Urokinase Plasminogen Activator as an Early Regulator of Obesity.

Arteriosclerosis, thrombosis, and vascular biology·2026
Same author

An antibody targeting high-molecular-weight kininogen blocks contact system activation in a model of polymicrobial sepsis.

Journal of thrombosis and haemostasis : JTH·2025
Same author

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons.

Cell reports·2025
Same author

Clinicopathological characteristics and prognostic outcomes of resectable hepatoid adenocarcinoma of the stomach: insights from a multicenter case-control study.

American journal of cancer research·2025
Same author

Synergistic effects of the Aβ/fibrinogen complex on synaptotoxicity, neuroinflammation, and blood-brain barrier damage in Alzheimer's disease models.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same journal

Body-Brain Integration: The Lower Brainstem in Sleep-Wake Regulation.

Annual review of neuroscience·2026
Same journal

Planning in the Brain: It's Not What You Think It Is.

Annual review of neuroscience·2026
Same journal

The Emerging Neurobiology of Psychedelics: Critical Periods, Metaplasticity, and Extracellular Matrix Remodeling.

Annual review of neuroscience·2026
Same journal

Rethinking Predictive Processing.

Annual review of neuroscience·2026
Same journal

Path Integration in Alzheimer's Disease: Orientation, Movement, and Theta Rhythmicity.

Annual review of neuroscience·2026
Same journal

The Cellular and Circuit Basis of Temperature Sensation in <i>Drosophila</i>.

Annual review of neuroscience·2026
See all related articles

Peripheral nerves regenerate after injury due to a supportive environment and neuron activation. This process involves axon regrowth and Schwann cell remyelination, crucial for functional recovery.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Regenerative Medicine

Background:

  • The central nervous system (CNS) has limited regenerative capacity after injury.
  • Peripheral nerves can regenerate spontaneously, facilitated by a permissive microenvironment.
  • Successful peripheral nerve regeneration depends on axon regrowth and Schwann cell-mediated remyelination.

Purpose of the Study:

  • To review the current understanding of peripheral axon regeneration.
  • To highlight the molecular factors and mechanisms governing Schwann cell remyelination.
  • To provide insights into the processes supporting nerve repair.

Main Methods:

  • Literature review of studies on peripheral nerve regeneration.
  • Analysis of molecular signaling pathways involved in Schwann cell function.

Related Experiment Videos

  • Focus on neurotrophic factors, extracellular matrix (ECM) proteins, and hormones.

    • Main Results:

    • Peripheral nerve regeneration involves coordinated cellular and molecular events.
    • Schwann cells dedifferentiate, proliferate, and migrate to aid regeneration.
    • Specific molecules like neurotrophic factors, ECM proteins, and hormones are critical for remyelination.

    Conclusions:

    • Peripheral nerve regeneration is a complex process involving intrinsic neuronal capacity and extrinsic factors.
    • Schwann cell activity, regulated by various molecules, is essential for successful remyelination.
    • Understanding these mechanisms could lead to therapeutic strategies for nerve repair.