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Updated: Jul 16, 2026
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Low dietary sodium and exogenous angiotensin II infusion decrease plasma adiponectin concentrations in healthy men
A Titia Lely1, Jan A Krikken, Stephan J L Bakker
1Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands. a.t.lely@int.umcg.nl
The Journal of Clinical Endocrinology and Metabolism
|March 8, 2007
Summary
The renin-angiotensin aldosterone system (RAAS) regulates adiponectin levels in humans. Angiotensin II infusion decreased adiponectin, while RAAS blockade increased it, suggesting therapeutic potential.
Area of Science:
- Endocrinology
- Cardiovascular Physiology
Background:
- Adiponectin exhibits anti-inflammatory and vascular protective properties, potentially improving insulin sensitivity.
- Animal studies indicate the renin-angiotensin aldosterone system (RAAS) influences adiponectin regulation.
Purpose of the Study:
- To investigate the role of the RAAS in regulating human adiponectin levels in vivo.
- To examine the effects of physiological and pharmacological RAAS modulation on plasma adiponectin.
Main Methods:
- Thirty-five healthy males underwent low-sodium and high-sodium diet periods.
- Plasma adiponectin was measured at baseline and during angiotensin II infusion.
- Effects of enalapril (ACE inhibition) on adiponectin were assessed during high-sodium intake.
Main Results:
- High-sodium diet (suppressing RAAS) significantly increased adiponectin levels.
- Angiotensin II infusion markedly decreased adiponectin concentrations.
- Enalapril treatment led to a significant increase in adiponectin.
Conclusions:
- RAAS modulation significantly impacts plasma adiponectin concentrations in humans.
- Lower adiponectin levels were observed under conditions of high angiotensin II activity.
- RAAS blockade warrants further investigation for treating hypoadiponectinemia.
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