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Intravenous immunoglobulins improve the function and ameliorate joint involvement in systemic sclerosis: a pilot
F Nacci1, A Righi, M L Conforti
1Department of Medicine and Surgery, University of Florence, Italy.
Annals of the Rheumatic Diseases
|March 9, 2007
Summary
Intravenous immunoglobulin therapy significantly improved hand function and reduced joint pain in systemic sclerosis patients with severe joint involvement. This treatment offers a potential option for patients unresponsive to other therapies.
Area of Science:
- Rheumatology
- Immunology
Background:
- Systemic sclerosis (SSc) often causes hand joint dysfunction.
- Intravenous immunoglobulins (IVIg) have shown prior benefit in SSc patients.
Purpose of the Study:
- To assess the efficacy of IVIg in treating joint involvement and improving hand function in SSc patients.
Main Methods:
- Seven women with severe, refractory SSc-related joint issues received IVIg (2 g/kg/month for 6 months).
- Evaluations included Ritchie Index, Dreiser Algo-Functional Index, VAS pain scale, HAQ, and modified Rodnan Skin Score.
Main Results:
- Significant reductions in joint pain (VAS) and improvements in hand function (IAFD) and quality of life (HAQ) were observed.
- Skin involvement also significantly improved (modified Rodnan Skin Score).
- One patient showed no significant improvement.
Conclusions:
- IVIg shows promise in alleviating joint pain and tenderness and restoring joint function in SSc patients with severe, refractory joint disease.
- Cost may restrict IVIg use to patients refractory to disease-modifying antirheumatic drugs.
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