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Updated: Jul 16, 2026
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Formation of Human Prostate Epithelium Using Tissue Recombination of Rodent Urogenital Sinus Mesenchyme and Human Stem Cells
Published on: June 22, 2013
Recurrent prostatic stromal sarcoma with massive high-grade prostatic intraepithelial neoplasia
Teppei Morikawa1, Akiteru Goto, Kyoichi Tomita
1Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. tmorikawa-tky@umin.ac.jp
Journal of Clinical Pathology
|March 10, 2007
Summary
Prostatic stromal sarcoma (PSS) can recur with significant high-grade prostatic intraepithelial neoplasia. This case suggests both stromal and epithelial components of PSS may possess malignant potential.
Area of Science:
- Oncology
- Uropathology
Background:
- Prostatic stromal sarcoma (PSS) is a rare malignant tumor.
- This report details a unique case of recurrent PSS.
Observation:
- A 52-year-old male presented with urinary retention and underwent radical cystoprostatectomy.
- Tumor analysis revealed an admixture of hyperplastic glands and spindle cell stroma, consistent with PSS.
Findings:
- Recurrent tumors appeared 66 months post-surgery in the pelvic cavity.
- These biphasic neoplasms showed prominent epithelial components with high-grade prostatic intraepithelial neoplasia-like atypia.
Implications:
- Findings suggest that the epithelial component of PSS may also harbor malignant potential.
- This highlights the need for careful evaluation of both stromal and epithelial elements in PSS recurrence.
