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Updated: Jul 16, 2026

An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
Published on: November 8, 2024
A study on functional similarity between dengue non structural protein 1 and platelet integrin/adhesin protein, CD61
1Department of Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 10330. wviroj@pioneer.netserv.chula.ac.th
Background:
Dengue infection is a major public health problem. The mechanisms underlying severe bleeding in dengue DHF are not completely understood. It was proposed that the dengue virus nonstructural-1 protein (DNS1) generated antibodies to common epitopes on human blood clotting and integrin/adhesin proteins on the platelet. The proof on the functional correlation between DNS1 and platelet integrin/adhesin proteins is needed.
Methods:
Here, the author used a new gene ontology technology to predict the molecular function and biological process of DNS1 and platelet integrin/adhesin protein, CD61.
Result:
According to this study, the author can identify no function and biological process of DNS1. Also, there is no existence of functional similarity between DNS1 and CD61.
Conclusion:
The hypothesis on role of molecular mimicry between DNS1 and CD61 is not supported in this study.
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