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Updated: Jul 16, 2026
12:28
Establishing Cell Lines Overexpressing DR3 to Assess the Apoptotic Response to Anti-mitotic Therapeutics
Published on: January 11, 2019
Recent progress in discovery and development of antimitotic agents
Alex Kiselyov1, Konstantin V Balakin, Sergey E Tkachenko
1ChemDiv, Inc. 11558 Sorrento Valley Rd., Ste. 5, San Diego, CA 92121, USA. ask@chemdiv.com
Anti-Cancer Agents in Medicinal Chemistry
|March 14, 2007
Summary
This review explores diverse antimitotic agents, focusing on microtubule dynamics modulation. Tubulin-binding drugs are key anticancer therapies, with other mitotic targets also discussed.
Area of Science:
- Pharmacology
- Oncology
- Cell Biology
Background:
- Antimitotic agents are crucial in cancer therapy.
- Microtubule dynamics modulation is a key mechanism.
- Tubulin-binding agents represent a significant class of anticancer drugs.
Purpose of the Study:
- To review the structural diversity of antimitotic agents.
- To highlight current therapies targeting microtubule dynamics.
- To discuss compounds targeting mitotic kinases and kinesins.
Main Methods:
- Literature review of antimitotic agents.
- Emphasis on tubulin-binding compounds.
- Discussion of agents targeting mitotic kinases and kinesins.
Main Results:
- Structural diversity of antimitotic agents is significant.
- Microtubule dynamics modulation is a primary therapeutic strategy.
- Tubulin-binding agents are well-established anticancer drugs.
Conclusions:
- Antimitotic agents, particularly tubulin binders, are vital in cancer treatment.
- Ongoing research explores diverse targets including kinases and kinesins.
- Modulation of microtubule dynamics remains a cornerstone of antimitotic therapy.
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