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Gelatin Nanocarriers as Biocompatible Platforms for Targeted Drug Delivery in Cancer Therapy
Lalit Kumar1,2, Vikas Aggarwal3, Komal Komal4
1Department of Pharmaceutics, Shiva Institute of Pharmacy, Chandpur, Bilaspur, H.P. 174004, India.
Anti-Cancer Agents in Medicinal Chemistry
|August 11, 2026
Summary
Gelatin nanoparticles offer a promising approach for targeted cancer therapy, improving drug delivery and reducing toxicity. Further research is needed to overcome challenges for clinical application.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Pharmacology
Background:
- Cancer remains a significant global health challenge requiring innovative therapeutic strategies.
- Gelatin-based nanocarriers present a biocompatible and stimuli-responsive platform for targeted cancer treatment.
- These nanocarriers address limitations associated with conventional cancer therapies.
Purpose of the Study:
- To review the application of gelatin nanoparticles for effective anticancer drug delivery.
- To explore recent advancements and challenges in the field from 2015-2025.
Main Methods:
- Comprehensive literature search across PubMed, ScienceDirect, and Google Scholar.
- Inclusion of studies and patents related to gelatin nanoparticles for cancer therapy from 2015 to 2025.
Main Results:
- Gelatin nanoparticles demonstrate reduced systemic toxicity and enhanced drug targeting in various cancers (lung, breast, melanoma).
- Synergistic effects observed when combined with therapies like ultrasound or photothermal treatment, improving cellular absorption and drug release.
- Patents reflect growing interest in diagnostic and therapeutic applications of these nanocarriers.
Conclusions:
- Gelatin nanocarriers offer versatile, stimuli-responsive drug release for improved cancer treatment outcomes.
- Challenges include scalable production, nanoparticle stability, and predictable drug release, hindering clinical translation.
- Emerging strategies like stimuli-responsive and size-transformable nanoparticles are being developed to overcome these hurdles.
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