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Updated: Aug 5, 2026
08:04
In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function
Published on: February 27, 2019
Rechallenge Therapy: New Dimensions in Cancer Therapy
Himanshu Singh1, Rajnish Kumar1, Avijit Mazumder2
1Department of Pharmaceutical Chemistry, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, U.P., 201306, India.
Anti-Cancer Agents in Medicinal Chemistry
|July 28, 2026
Summary
Rechallenge therapy, reintroducing prior cancer treatments, shows promise for overcoming resistance and treating recurrence. Careful patient selection and scientific strategy are key to optimizing outcomes across various cancer types.
Area of Science:
- Oncology
- Cancer Therapeutics
- Drug Resistance
Background:
- Cancer therapy resistance is a major challenge, limiting treatment options and leading to disease progression.
- Rechallenge therapy, reintroducing a previously used treatment after a break, is a potential strategy to overcome resistance.
Purpose of the Study:
- To synthesize current knowledge on rechallenge therapy across various cancer types and therapeutic classes.
- To analyze the efficacy and influencing factors of rechallenge strategies.
Main Methods:
- Comprehensive review of clinical trials, retrospective studies, and case reports.
- Examination of immunotherapy, chemotherapy, targeted therapy, hormonal therapy, and combination approaches.
Main Results:
- Rechallenge therapy efficacy varies by cancer type; examples include anti-EGFR in colorectal cancer (20-30% response) and hormonal therapy in breast cancer (>40% benefit).
- Prostate cancer rechallenge with ADT or abiraterone showed 30-40% biochemical response rates.
Conclusions:
- Rechallenge therapy offers a promising approach for managing cancer recurrence and resistance.
- Optimizing rechallenge requires careful patient tailoring, predictive biomarker identification, and understanding long-term outcomes.
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