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A 1H-NMR study of the solution conformation of cyclo(GRGDSPA): conformational effects on the physiological activity
R Mizutani1, I Shimada, Y Ueno
1Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Biochemical and Biophysical Research Communications
|January 31, 1992
Abstract:
Solution conformations of cyclo(GRGDSPA) have been analyzed by the use of two-dimensional proton nuclear magnetic resonance spectroscopy and the dynamical simulated annealing calculation. It has been shown that the RGDS segment in cyclo(GRGDSPA) takes a beta-turn conformation. We have concluded that this beta-turn conformation is essential for the physiological activity of cyclo(GRGDSPA).