Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Peritoneal Dialysis III: Nursing Management01:25

Peritoneal Dialysis III: Nursing Management

Peritoneal dialysis, or PD, utilizes the peritoneal membrane as a filter to eliminate excess fluid and waste products. Effective nursing management is essential for ensuring patient safety, preventing complications, and promoting optimal function of the peritoneal dialysis process.Assessment and MonitoringNurses must thoroughly assess the patient before, during, and after each dialysis session. Regular monitoring includes vital signs, daily weight, fluid intake and output, and laboratory values...
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autoantibodies to apolipoprotein A-I in hepatitis C virus infection: a role in disease progression?

Frontiers in immunology·2025
Same author

Standardising lipid testing and reporting in the United Kingdom; a joint statement by HEART UK and The Association for Laboratory Medicine.

Annals of clinical biochemistry·2025
Same author

Lipoprotein(a) testing in lipid clinics across the UK: Results of a national survey.

Journal of clinical lipidology·2024
Same author

Lipoprotein(a) and cardiovascular disease: sifting the evidence to guide future research.

European journal of preventive cardiology·2024
Same author

Reduced trabecular bone mineral density and thinner cortices in men with distal forearm fractures.

Bone·2022
Same author

Mechanical-Stress-Related Epigenetic Regulation of <i>ZIC1</i> Transcription Factor in the Etiology of Postmenopausal Osteoporosis.

International journal of molecular sciences·2022

Related Experiment Video

Updated: Jul 16, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Hepatic surgery-related hypophosphatemia.

Harish K Datta1, Mahdi Malik, R Dermot G Neely

  • 1Department of Clinical Biochemistry and Metabolism, Royal Victoria Infirmary, Newcastle upon Tyne, NE1 4LP, UK. h.k.datta@ncl.ac.uk

Clinica Chimica Acta; International Journal of Clinical Chemistry
|March 14, 2007
PubMed
Summary

Post-surgical hypophosphatemia (HP), common after liver transplants, is likely caused by excessive urinary phosphate loss, not liver uptake. Understanding phosphatonins may improve HP management.

Related Experiment Videos

Last Updated: Jul 16, 2026

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver
09:02

Percutaneous Hepatic Perfusion (PHP) with Melphalan as a Treatment for Unresectable Metastases Confined to the Liver

Published on: July 31, 2016

Area of Science:

  • Nephrology
  • Endocrinology
  • Surgical Pathophysiology

Background:

  • Post-surgical hypophosphatemia (HP) is prevalent, especially after liver transplantation.
  • Current understanding and management guidelines for HP are lacking.
  • Pathogenesis is debated, with theories including increased phosphate utilization by the liver or enhanced urinary losses.

Purpose of the Study:

  • To review the pathophysiology of post-surgical HP.
  • To provide evidence supporting urinary phosphate loss as the primary mechanism.
  • To discuss the role of phosphatonins in mediating HP and cellular Pi depletion.

Main Methods:

  • Literature review focusing on the pathophysiology of post-surgical hypophosphatemia.
  • Analysis of evidence for proposed mechanisms of phosphate imbalance.
  • Discussion of emerging roles for phosphatonins in phosphate homeostasis.

Main Results:

  • Evidence suggests excessive urinary phosphate loss, rather than increased hepatic uptake, is the main driver of post-surgical HP.
  • Phosphatonins are implicated as potential mediators of this urinary loss.
  • Cellular Pi depletion has significant biochemical consequences impacting patient management.

Conclusions:

  • Urinary phosphaturic factors (phosphatonins) likely play a critical role in post-operative HP following liver transplantation.
  • Further investigation into phosphatonins is needed to identify specific factors and elucidate mechanisms.
  • Improved understanding of HP pathophysiology and cellular Pi depletion can enhance patient monitoring and management strategies.