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Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
Published on: June 21, 2018
Age, Gene/Environment Susceptibility-Reykjavik Study: multidisciplinary applied phenomics
Tamara B Harris1, Lenore J Launer, Gudny Eiriksdottir
1Laboratory of Epidemiology, Demography, and Biometry, Intramural Research Program, National Institute on Aging, Bethesda, MD 20892-9205, USA. Harris99@mail.nih.gov
American Journal of Epidemiology
|March 14, 2007
Summary
The Age, Gene/Environment Susceptibility-Reykjavik Study (AGES-Reykjavik) investigates aging risk factors. It aims to identify genetic and environmental influences on age-related diseases and healthy aging in an older population.
Area of Science:
- Gerontology and genetics research.
- Multidisciplinary study of aging.
Background:
- Initiated in 2002, AGES-Reykjavik anticipates human genome and proteome data.
- Leverages the established, population-based Reykjavik Study cohort.
Purpose of the Study:
- Examine risk factors for disease and disability in old age.
- Investigate genetic susceptibility and gene/environment interactions.
- Identify genetic factors contributing to healthy aging and chronic conditions.
Main Methods:
- Detailed phenotypes of cardiovascular, neurocognitive, musculoskeletal systems, body composition, and metabolic regulation.
- Utilizes biomarkers, imaging, and physiologic indicators for quantitative traits and disease indicators.
- Draws sample from a genetically homogeneous older Icelandic population.
Main Results:
- Detailed late-life phenotypes and early-life cardiovascular risk factor assessments.
- Comprehensive study of aging nested within a specific population.
- Facilitates identification of genetic factors in aging and disease.
Conclusions:
- The AGES-Reykjavik study provides a robust platform for aging research.
- Aims to enhance understanding of genetic and environmental impacts on aging.
- Expected to identify key genetic contributors to healthy and unhealthy aging.
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