Growth deceleration and restoration after serious burn injury

Kathy Prelack1, Johanna Dwyer, Gerry E Dallal

  • 1Nutrition Suport, Shriners Hospitals for Children, Boston, Massachusetts 02114, USA.

Insights

Pediatric burn survivors with massive burns (≥50% TBSA) may experience modest growth deceleration, impacting stature. However, most burned children do not show significant long-term growth deficits after injury.

Area of Science:

  • Pediatric burn care
  • Growth and development
  • Trauma recovery

Background:

  • A common belief suggests burned children face growth deceleration, but data on its extent and duration are limited.
  • This lack of information hinders effective treatment decisions for pediatric burn patients.

Purpose of the Study:

  • To describe the natural history of growth in children after severe burn injuries.
  • To quantify the prevalence, duration, and degree of growth deceleration in this population.

Main Methods:

  • Retrospective review of 159 pediatric patients (<13 years) with burns ≥30% Total Body Surface Area (TBSA).
  • Analysis of height and weight Z scores from admission and subsequent hospitalizations.
  • Comparison of post-burn Z scores to baseline to assess growth recoupment.

Main Results:

  • Massively burned children (≥50% TBSA) showed significant, sustained declines in height-for-age Z scores (0.50–0.76 units), equating to a 1.6–5.8 cm deficit.
  • 11% of massively burned children exhibited stunting (height-for-age Z scores consistent with stunting).
  • Weight-for-age Z scores were generally unaffected, except in massively burned children up to 1.5 years post-burn.

Conclusions:

  • Only pediatric patients with massive burns (≥50% TBSA) demonstrated a statistically significant decline in stature.
  • The observed growth deceleration in massively burned children was generally modest.
  • Further research may be needed to understand the long-term implications and optimize interventions for growth in severely burned children.

Related Concept Videos

Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Healing I: Introduction01:11

Healing I: Introduction

Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Healing II: Complications01:24

Healing II: Complications

Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Phases of Wound Repair01:28

Phases of Wound Repair

Following injury, the integrity of the injured tissues must be reestablished. For example, in skin tissue, wound repair involves coordination among resident skin cells, blood mononuclear cells, extracellular matrix, growth factors, and cytokines to complete the healing cascade.
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...