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A Swine Burn Model for Investigating the Healing Process in Multiple Depth Burn Wounds
Published on: February 23, 2024
Growth deceleration and restoration after serious burn injury
Kathy Prelack1, Johanna Dwyer, Gerry E Dallal
1Nutrition Suport, Shriners Hospitals for Children, Boston, Massachusetts 02114, USA.
Insights
Pediatric burn survivors with massive burns (≥50% TBSA) may experience modest growth deceleration, impacting stature. However, most burned children do not show significant long-term growth deficits after injury.
Area of Science:
- Pediatric burn care
- Growth and development
- Trauma recovery
Background:
- A common belief suggests burned children face growth deceleration, but data on its extent and duration are limited.
- This lack of information hinders effective treatment decisions for pediatric burn patients.
Purpose of the Study:
- To describe the natural history of growth in children after severe burn injuries.
- To quantify the prevalence, duration, and degree of growth deceleration in this population.
Main Methods:
- Retrospective review of 159 pediatric patients (<13 years) with burns ≥30% Total Body Surface Area (TBSA).
- Analysis of height and weight Z scores from admission and subsequent hospitalizations.
- Comparison of post-burn Z scores to baseline to assess growth recoupment.
Main Results:
- Massively burned children (≥50% TBSA) showed significant, sustained declines in height-for-age Z scores (0.50–0.76 units), equating to a 1.6–5.8 cm deficit.
- 11% of massively burned children exhibited stunting (height-for-age Z scores consistent with stunting).
- Weight-for-age Z scores were generally unaffected, except in massively burned children up to 1.5 years post-burn.
Conclusions:
- Only pediatric patients with massive burns (≥50% TBSA) demonstrated a statistically significant decline in stature.
- The observed growth deceleration in massively burned children was generally modest.
- Further research may be needed to understand the long-term implications and optimize interventions for growth in severely burned children.
Abstract:
There is a common perception that burned children are at risk for growth deceleration. However, because the prevalence, duration, and degree of this stereotypic growth are poorly described, making informed decisions about treatment is difficult. This article describes the natural history of growth after burn injury, according to the findings of a retrospective review conducted in a regional pediatric burn center. The study population comprised children younger than 13 years at the time of injury, who survived burns involving >or=30% TBSA. Main outcome measures were height and weight; values obtained upon admission for burn injury and at all subsequent hospital admissions were converted to height-for-age and weight-for-age Z scores with use of a reference standard. Z scores were then used to determine whether baseline height and weight status (according to initial admission data) were recouped after burn injury. Medical records of 159 patients (2910 admissions) were reviewed. Children with massive burns (>or=50% TBSA) had height-for-age Z scores that were significantly below their baseline average for all years studied (mean fall in Z score units of 0.50-0.76; P < .0001). This decline in height-for-age Z scores represented a deficit of 1.6 to 5.8 cm. Seventeen patients (11%) had height-for-age Z scores consistent with stunting. Weight-for-age Z scores were not statistically lower than the reference standard, except for patients with massive burns up to 1.5 years post-burn. In our population of burned children, only massively burned children demonstrated a decline in stature. The decline for most was modest.
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