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Updated: Jul 16, 2026

Scoring Central Nervous System Inflammation, Demyelination, and Axon Injury in Experimental Autoimmune Encephalomyelitis
Published on: February 23, 2024
High CSF neurofilament heavy chain levels in neuromyelitis optica
I Miyazawa1, I Nakashima, A Petzold
1Department of Neurology, Tohoku University School of Medicine, Seiryo-machi, Aoba-ku, Sendai, Japan.
Abstract:
The neurofilament heavy chain (NfHSMI35), a biomarker of axonal damage in the CSF, was measured in patients with neuromyelitis optica (NMO) and multiple sclerosis (MS). Significantly high CSF NfHSMI35 levels (>0.73 ng/mL) were found in 6 of 24 (25%) of the patients with NMO but none of the patients with MS (0/24). This finding suggests that axonal damage is more severe in NMO than in MS.
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