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Related Experiment Video

Updated: Jul 16, 2026

Murine Prostate Micro-dissection and Surgical Castration

Murine Prostate Micro-dissection and Surgical Castration

Published on: May 11, 2016

Androgen deficiency in older men.

G Valenti¹, G Ceresini, M Maggio

¹Section of Geriatrics, Department of Internal Medicine and Biomedical Sciences, University of Parma, Via Gramsi 14, 42100 Parma, Italy. giorgiovalenti@libero.it

Minerva Ginecologica

|March 14, 2007

Summary

Androgen deficiency in older men impacts somatic, sexual, and psychological health due to neuro-endocrine changes. Treatments include testosterone and dehydroepiandrosterone, with new targeted therapies showing promise.

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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

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Published on: March 6, 2018

Area of Science:

Endocrinology
Geriatrics
Men's Health

Background:

Aging in men is associated with neuro-endocrine changes affecting testicular and adrenal hormone production.
Androgen deficiency can manifest with significant clinical consequences across multiple physiological systems.

Purpose of the Study:

To review the clinical consequences of androgen deficiency in older men.
To explore current and potential therapeutic interventions for androgen deficiency.

Main Methods:

A review of observational studies and randomized placebo-controlled trials from medical literature.
Analysis of clinical consequences across somatic, sexual, and psychological domains.

Main Results:

Androgen deficiency affects body composition, metabolism, erythropoiesis, sexual function, cognition, and affectivity.
Testosterone (transdermal gel) and dehydroepiandrosterone are established treatment options.
Novel compounds targeting androgen receptors offer potential anabolic benefits.

Conclusions:

Androgen deficiency in aging men has wide-ranging clinical impacts.
Hormone replacement therapy, particularly with testosterone, can address these deficiencies.
Targeted therapies represent a future direction for managing androgen deficiency and its consequences.