Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Bacterial Phylum Chlamydiae

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic of...

Sexually Transmitted Infections

Sexually Transmitted Infections

Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...

Trichomoniasis

Trichomoniasis

Trichomonas vaginalis is a flagellated protozoan parasite and the causative agent of trichomoniasis, one of the most prevalent non-viral sexually transmitted infections in the United States. This extracellular parasite primarily colonizes the lower genitourinary tract in women—particularly the vagina—and in men, the urethra and prostate. Its structural and functional adaptations enable its survival, motility, and pathogenicity within the host environment.Structural Features and Host EntryT.

Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

Factors Affecting the Risk of Infection

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...

Amebiasis

Amebiasis

Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Novel and High-Throughput Method of Isolating Single Fetal Cells Using FACS for NIPT.

Prenatal diagnosis·2026

Same author

The impact of uncertainty on disclosure of prenatal exome sequencing results: A vignette study among medical students.

PloS one·2026

Same author

Acute kidney injury and chronic kidney disease in individuals with Down syndrome: a nationwide cohort study.

Clinical kidney journal·2026

Same author

Discrepancy in menstrual and ultrasound-based gestational age is associated with chromosomal aberrations and adverse pregnancy outcomes-Results from a nationwide cohort study.

Acta obstetricia et gynecologica Scandinavica·2026

Same author

A qualitative study of parents' experiences with receiving a prenatal diagnosis of confined placental mosaicism - "We had nothing to rely on, you know?"

Journal of genetic counseling·2026

Same author

Coping with rejection as a sperm donor: A qualitative study of the personal impact of rejection and new health information.

PloS one·2025

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

Forward Genetic Approaches in Chlamydia trachomatis

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

Chlamydia trachomatis C-complex serovars are a risk factor for preterm birth.

Stine Hollegaard¹, Ida Vogel, Poul Thorsen

¹NANEA, Department of Epidemiology, Institute of Public Health, University of Aarhus, 8000 Aarhus C, Denmark.

In Vivo (Athens, Greece)

|March 16, 2007

Summary

Previous Chlamydia trachomatis C-complex infections increase the risk of spontaneous preterm birth (PTB). This infection may also contribute to subfertility, infertility, and ectopic pregnancy, highlighting a significant public health concern.

More Related Videos

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Published on: August 11, 2012

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Published on: January 30, 2020

Related Experiment Videos

Last Updated: Jul 16, 2026

Forward Genetic Approaches in Chlamydia trachomatis

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Published on: August 11, 2012

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Markerless Gene Deletion by Floxed Cassette Allelic Exchange Mutagenesis in Chlamydia trachomatis

Published on: January 30, 2020

Area of Science:

Reproductive Health
Infectious Diseases
Obstetrics

Background:

Chlamydia trachomatis (C. trachomatis) infections are common sexually transmitted infections.
The potential link between C. trachomatis and adverse pregnancy outcomes, such as preterm birth, requires further investigation.
Understanding these associations can inform public health strategies and clinical management.

Purpose of the Study:

To investigate the association between C. trachomatis infections (IgG and serovars) and spontaneous preterm birth (PTB).
To explore the relationship between C. trachomatis infections and previous fertility issues, including subfertility, infertility treatment, and ectopic pregnancy.

Main Methods:

Chlamydia antigen, Chlamydia IgG, and specific C. trachomatis complex levels were measured at 17 weeks gestation.
Spontaneous preterm birth (<37 weeks) was the primary outcome.
Logistic regression was used to estimate relative risks (RR) and odds ratios (OR) for associations.

Main Results:

C. trachomatis C-complex positivity was significantly associated with spontaneous PTB (RR 2.6).
A history of C. trachomatis C-complex infection was linked to subfertility (OR 4.4), infertility treatment (OR 7.2), and ectopic pregnancy (OR 5.2).

Conclusions:

Previous C. trachomatis C-complex infection is associated with an elevated risk of spontaneous preterm birth.
C. trachomatis C-complex infection may be a contributing factor to subfertility, infertility, and ectopic pregnancy.
These findings underscore the importance of screening and managing C. trachomatis infections in women of reproductive age.