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Long-acting oral bromocriptine (Parlodel SRO) in the treatment of hyperprolactinemia
C O Weingrill1, W Mussio, C R Moraes
1Department of Medicine, Escola Paulista de Medicina, Sao Paulo, Brazil.
Objectives:
To compare the effect of Parlodel SRO (Sandoz, Basel, Switzerland), a long-acting oral bromocriptine, to Parlodel (Sandoz) and to study the chronic effects of Parlodel SRO.
Design:
The study was twofold: (1) random, double-blind and (2) open.
Setting:
Patients were studied in an academic environment.
Patients:
Hyperprolactinemic patients were selected. Sixteen patients were treated during 1 month. Ten patients completed the 1-year follow-up.
Interventions:
Parlodel SRO or Parlodel was administered during 1 month (first 15 days: 5 mg/d; afterwards: 10 mg/d). Parlodel SRO was given during 1 year in variable doses (maximal 20 mg/d).
Main Outcome Measures:
Prolactin (PRL) levels, clinical improvement, and side effects were evaluated.
Results:
After 1 month, 63% of the patients in both groups had normal PRL and 43% had menses. Side effects were similar. After 1 year all patients except one had normal PRL levels, and 89% were ovulating.
Conclusions:
The efficacy, tolerability, and long duration of action of Parlodel SRO make it an excellent alternative for the treatment of hyperprolactinemic patients.