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Updated: Jul 31, 2026

Dechorionation of Medaka Embryos and Cell Transplantation for the Generation of Chimeras
Published on: December 22, 2010
Chimerism as the etiology of a 46,XX/46,XY fertile true hermaphrodite
M S Verp1, H H Harrison, C Ober
1Department of Obstetrics and Gynecology, Chicago Lying-In Hospital, Illinois.
Objective:
To determine the conceptional events resulting in a 46,XX/46,XY true hermaphrodite and to report the first pregnancy in a 46,XX/46,XY true hermaphrodite with an ovotestis.
Design:
Chromosome studies were performed on patient lymphocytes and fibroblasts. Red cell antigens, human leukocyte antigens, and presence of Y-chromosome deoxyribonucleic acid were analyzed. Findings were compared with parental and sibling blood group data.
Setting:
Genetics clinic and laboratories of a university hospital.
Results:
These studies demonstrated that our patient is a chimera, with dual maternal and paternal contributions. In addition, despite the presence of an ovotestis, she conceived and delivered a child.
Conclusions:
The mechanism for chimerism in this case could be fertilization of (1) the secondary oocyte and first polar body; (2) the ovum and first polar body; (3) the ovum and second polar body; or (4) fusion of two embryos.
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