Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alcoholic liver disease.

William W Yip1, Alastair D Burt

  • 1Department of Pathology, Alice Ho Miu Ling Nethersole Hospital, Tai Po, New Territories, Hong Kong.

Seminars in Diagnostic Pathology
|March 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Head to head: should portal inflammation be part of grading necroinflammatory activity in metabolic dysfunction-associated steatotic liver disease?

Histopathology·2026
Same author

Investigating the mechanisms of indocyanine green tumour uptake in sarcoma cell lines and ex vivo human tissue.

The Journal of pathology·2025
Same author

The changing landscape of liver transplantation and the role of histopathology.

Histopathology·2024
Same author

Making Sense of 'Porto-Sinusoidal Vascular Disorder': What Does It Mean for the Pathologist and the Patient?

Liver international : official journal of the International Association for the Study of the Liver·2024
Same author

AI-based automation of enrollment criteria and endpoint assessment in clinical trials in liver diseases.

Nature medicine·2024
Same author

Steatohepatitic hepatocellular Carcinoma:A new approach to classifying morphological subtypes of hepatocellular carcinoma.

Human pathology·2024
Same journal

Update on the molecular pathology of the distinctive giant cell, fibro-osseous and bone forming lesions of the jaws.

Seminars in diagnostic pathology·2026
Same journal

Update on the molecular pathology and classification of odontogenic cysts and tumours.

Seminars in diagnostic pathology·2026
Same journal

MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.

Seminars in diagnostic pathology·2026
Same journal

When three negatives equal a positive: Molecular updates of triple-negative breast carcinomas with favorable prognoses.

Seminars in diagnostic pathology·2026
Same journal

Old school, new insight: Revisiting histomorphology in the modern era of prostate cancer risk stratification.

Seminars in diagnostic pathology·2026
Same journal

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology·2026
See all related articles

Excessive alcohol intake causes a range of liver diseases, including steatosis, steatohepatitis, cirrhosis, and liver cancer. Histological assessment of liver biopsy is crucial for grading severity and prognosis in alcoholic liver disease.

Area of Science:

  • Hepatology
  • Pathology
  • Gastroenterology

Background:

  • Alcoholic liver disease (ALD) encompasses a spectrum of conditions from simple steatosis to hepatocellular carcinoma.
  • Key features include hepatocyte ballooning degeneration and apoptosis, with fibrosis progression leading to cirrhosis.

Purpose of the Study:

  • To review the histological spectrum of alcoholic liver disease.
  • To discuss prognostic indicators and a proposed grading and staging schema for histological assessment.

Main Methods:

  • Review of existing literature on the histopathology of ALD.
  • Incorporation of a proposed grading and staging schema for histological severity.

Main Results:

  • ALD progression involves steatosis, steatohepatitis, fibrosis, cirrhosis, and potentially hepatocellular carcinoma.

Related Experiment Videos

  • Apoptosis and specific fibrosis patterns (perivenular, centrilobular) are critical features.
  • Abstinence and comorbid conditions influence ALD morphology and clinical presentation.

    • Conclusions:

    • Histological evaluation of liver biopsies is vital for diagnosing and staging ALD.
    • A proposed grading and staging system can provide prognostic information.
    • Understanding the diverse histological manifestations aids in managing ALD.