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Motor development in school-aged children with 22q11 deletion (velocardiofacial/DiGeorge syndrome)

Katrijn Van Aken1, Bert De Smedt, Annelies Van Roie

  • 1Faculty of Kinesiology and Rehabilitation Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. katrijn.vanaken@faber.kuleuven.be

Developmental Medicine and Child Neurology
|March 16, 2007
PubMed

Insights

Children with 22q11 deletion syndrome exhibit significant motor development deficits compared to peers. Intelligence quotient (IQ) impacts motor skills in this group, but congenital heart defects do not.

Area of Science:

  • Pediatric Neurology
  • Developmental Psychology
  • Genetics

Background:

  • 22q11 deletion syndrome (del22q11) is a genetic disorder associated with various developmental challenges.
  • Motor development is crucial for childhood development and functional independence.
  • Previous research indicates potential neurodevelopmental impacts of del22q11, but specific motor function deficits require further elucidation.

Purpose of the Study:

  • To compare the motor development of primary school children with del22q11 to a control group.
  • To investigate the influence of congenital heart defects (CHD) and IQ on motor development within the del22q11 cohort.

Main Methods:

  • Utilized the Bruininks-Oseretsky Test of Motor Proficiency to assess motor skills.
  • Compared motor performance between 37 children with del22q11 and 34 typically developing controls.
  • Analyzed the effects of IQ and CHD on motor outcomes in the del22q11 group.

Main Results:

  • Children with del22q11 demonstrated significantly poorer motor functioning compared to controls (p < 0.01).
  • A significant correlation was observed between IQ and motor performance in the del22q11 group.
  • Congenital heart defects did not show a significant impact on motor performance within the del22q11 cohort.

Conclusions:

  • Primary school children with 22q11 deletion syndrome experience substantial deficits in motor performance.
  • Intellectual quotient is a significant factor influencing motor skill development in children with del22q11.
  • Further research should explore targeted interventions to support motor development in this population.

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