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Possible pseudogout in two dogs.

S F Forsyth1, K G Thompson, J J Donald

  • 1Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand.

The Journal of Small Animal Practice
|March 16, 2007
PubMed
Summary
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Pseudogout, or calcium pyrophosphate deposition disease, is rarely diagnosed in animals. This study identified pseudogout in two dogs presenting with acute lameness and pyrexia, with crystals found in synovial fluid.

Area of Science:

  • Veterinary Medicine
  • Rheumatology
  • Crystallography

Background:

  • Pseudogout, the acute form of calcium pyrophosphate deposition disease (CPPD), is common in elderly humans.
  • CPPD is characterized by sudden onset of intense joint pain and synovitis.
  • Diagnosis in animals is rare.

Observation:

  • Two dogs presented with acute lameness and pyrexia.
  • Synovial fluid analysis revealed elevated cell counts with neutrophils and mononuclear cells.
  • Crystals, identified as calcium pyrophosphate dihydrate (CPPD), were observed within synovial fluid cells.

Findings:

  • Square or rhomboid-shaped crystals, weakly birefringent under polarized light, were identified.
  • These crystals were found within mononuclear cells and occasional neutrophils in the synovial fluid.

Related Experiment Videos

  • The canine cases exhibited clinical signs consistent with pseudogout.

    • Implications:

    • This study expands the understanding of CPPD occurrence in non-human species.
    • Highlights the importance of considering pseudogout in canine patients with acute lameness.
    • Suggests prednisolone as a potential treatment for canine pseudogout, warranting further investigation.