Related Experiment Video
Updated: Jul 16, 2026
07:48
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Granular cell tumors of the urinary bladder
Farhat Abbas1, Amanullah Memon, Tanya Siddiqui
1Department of Surgery (Urology), The Aga Khan University Hospital, Karachi, Pakistan. farhat.abbas@aku.edu
World Journal of Surgical Oncology
|March 16, 2007
Summary
This study presents two rare urinary bladder granular cell tumor (GCT) cases, one benign and one malignant. Prompt diagnosis and tailored surgical approaches, from conservative resection to radical surgery, ensure long-term disease-free survival for GCT patients.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Granular cell tumors (GCTs) are exceptionally rare bladder neoplasms, with limited reported cases.
- Typically of neural origin, GCTs can be mistaken for malignant tumors due to their appearance.
Observation:
- Two cases of GCTs, one benign and one malignant, are presented in female patients.
- Both patients presented with gross hematuria.
Findings:
- Histopathology confirmed GCTs, positive for S-100 neural marker and negative for epithelial, neuroendocrine, and sarcoma markers.
- Benign GCT treated with transurethral resection; malignant GCT required radical cystectomy with extensive surgical staging.
- Both treatment strategies resulted in long-term disease-free survival.
Implications:
- Accurate histopathological assessment is crucial for correct GCT diagnosis.
- Treatment should be tailored: conservative for benign GCTs and aggressive for localized malignant GCTs.
- These findings support effective management strategies for urinary bladder GCTs.
Related Concept Videos
01:23Urinary Bladder
The urinary bladder is a hollow, muscular sac that temporarily stores urine before it is expelled from the body. It can hold approximately 600 mL of urine prior to micturition. The bladder is retroperitoneal and located behind the pubic symphysis in the pelvic floor.
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
In males, the bladder is situated in front of the rectum, while in females, it is positioned anterior to the vagina and uterus. The bladder floor contains an inverted triangular area called the trigone, defined by the two ureteric...
01:19Anatomy of the Genitourinary System II: Bladder and Urethra
The lower urinary system consists of the urinary bladder and urethra, which are essential in storing and expelling urine from the body. Together with the internal and external sphincters, these structures work together to regulate urination effectively.Anatomy of the BladderThe urinary bladder is a muscular, stretchable organ behind the pubic bone and in front of the rectum. In females, the bladder is positioned anterior to the vagina and inferior to the uterus, while in males, it is located...
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
01:28Urinary Tract Calculi I: Introduction
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
01:26Nursing Assessment of the Genitourinary System II: Inspection and Palpation
The nursing assessment of the genitourinary (GU) system involves a systematic inspection and palpation to identify abnormalities in the kidneys, bladder, and surrounding structures.InspectionMouth: Inspect for signs of kidney dysfunction, such as stomatitis (inflammation of the mouth) and ammonia breath, which may occur in advanced kidney disease due to the buildup of urea, breaking down into ammonia.Skin: Check for pallor, which could indicate anemia caused by kidney disease. Look for...
01:20Disorders of the Urinary System
The urinary system is responsible for eliminating waste and excess fluids from the body. However, disorders of the urinary system can arise due to various reasons like infections, stress, age, congenital abnormalities, and lifestyle.
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...
Urinary tract infections (UTIs) are one of the most common urinary system disorders. They are caused by bacteria that enter the urethra and can spread to the bladder resulting in cystitis. Pyelonephritis is the result of a UTI that has ascended to the level of the...