Related Experiment Video
Updated: Jul 16, 2026
08:09
A Doxorubicin-induced Cardiomyopathy Model in Adult Zebrafish
Published on: June 7, 2018
Euthyroid Sick syndrome And Cardiac Failure In Zaria, Nigeria
S S Danbauchi1, F E Anumah, H S Isah
1Cardiology Unit, Ahmadu Bello University Teaching Hospital Zaria, Nigeria.
The Nigerian Postgraduate Medical Journal
|March 16, 2007
Summary
Sick euthyroid syndrome is present in Nigerian patients with cardiac failure. Low triiodothyronine (T3) levels correlate with severe heart failure, while normal thyroxine (T4) and thyroid-stimulating hormone (TSH) indicate this condition.
Area of Science:
- Cardiology
- Endocrinology
- Internal Medicine
Background:
- Cardiac failure is a complex condition affecting heart function.
- Euthyroid sick syndrome, characterized by altered thyroid hormone levels in non-thyroidal illness, is increasingly recognized.
- Understanding its pattern in cardiac failure is crucial for patient management.
Purpose of the Study:
- To establish the presence of sick euthyroid syndrome in Nigerian patients with cardiac failure.
- To investigate if this syndrome exhibits a unique pattern in this population.
Main Methods:
- A study involving 30 patients with cardiac failure (NYHA class 3-4) and 30 matched controls.
- Evaluations included clinical assessment, electrocardiography, chest radiography, echocardiography, and thyroid function tests (T3, T4, TSH).
Main Results:
- Patients with cardiac failure showed significantly lower T3 levels and higher T4 levels compared to controls.
- Thyroid-stimulating hormone (TSH) levels were similar between groups.
- Echocardiographic findings revealed impaired cardiac function in patients, with correlations between T3 levels and cardiac parameters like ejection fraction and left ventricular mass.
Conclusions:
- Sick euthyroid syndrome is present in Nigerians with cardiac failure, similar to findings elsewhere.
- Low serum T3 levels, with normal T4 and TSH, are associated with severe cardiac failure.
- T3 levels demonstrate inverse proportionality to cardiac structural changes and direct proportionality to cardiac function (ejection fraction, fractional shortening).
Related Concept Videos
01:30Cardiomyopathy II: Dilated Cardiomyopathy
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
01:27Heart Failure I: Introduction
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
01:17Pathophysiology of Heart Failure
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
01:29Cardiomyopathy VI: Nursing Management
Assessment: Nursing management of patients with cardiomyopathy begins with a thorough assessment of the patient's history, including a family history of cardiomyopathy or sudden cardiac death, personal history of heart disease, hypertension, diabetes, and any alcohol consumption or drug use.During the physical examination, assess vital signs, look for signs of heart failure (such as edema, jugular venous distention, and cyanosis), auscultate for abnormal heart sounds (like murmurs and gallops),...
01:26Heart Failure III: Clinical Manifestations
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
01:28Mechanism of Cardiac Arrhythmias
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.