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Related Concept Videos

Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

Triglycerides are a form of long-term energy storage molecules. They are made of glycerol and three fatty acids. To obtain energy from fat, triglycerides must first be broken down by hydrolysis into their two principal components, fatty acids and glycerol. This process, called lipolysis, takes place in the cytoplasm. The resulting fatty acids are oxidized by β-oxidation into acetyl-CoA, which is used by the Krebs cycle. The glycerol that is released from triglycerides after lipolysis directly...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution01:25

Pharmacokinetics in Obese Patients: Drug Absorption and Distribution

Obesity significantly alters the pharmacokinetic processes of drug absorption and distribution, presenting unique challenges in medical treatment. The increased fat tissue and decreased lean muscle in obese individuals can significantly affect how drugs are absorbed into the body and distributed across different tissues. This alteration can lead to variances in the effectiveness and safety of medications, necessitating adjustments in dosing or drug selection for obese patients.One notable...
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion01:20

Pharmacokinetics in Obese Patients: Drug Metabolism and Excretion

Drug metabolism, a critical process in the liver, involves two primary phases: Phase I reactions and Phase II conjugation. Obesity introduces significant alterations in this metabolic process, primarily due to fatty infiltration of the liver, leading to conditions such as nonalcoholic fatty liver disease (NAFLD). This condition can modify the activities of both Phase I and II enzymes, impacting how drugs are metabolized in obese patients.Phase I metabolism sees variable effects across...

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Related Experiment Video

Updated: Jul 16, 2026

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
10:30

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Metabolic effects associated with adipose tissue distribution.

B Zahorska-Markiewicz1

  • 1Department of Pathophysiology, Medical University of Silesia, Katowice, Poland. bmarkiewicz@slam.katowice.pl

Advances in Medical Sciences
|March 16, 2007
PubMed
Summary

Abdominal obesity, not just overall weight, strongly predicts cardiovascular and metabolic risks. Adipose tissue secretes proteins (adipokines) that worsen insulin resistance, inflammation, and atherosclerosis.

Area of Science:

  • Endocrinology
  • Metabolic Syndrome
  • Cardiovascular Disease

Background:

  • Obesity is linked to cardiovascular and metabolic diseases.
  • Fat distribution, particularly abdominal obesity, is a key predictor of health risks.
  • Adipose tissue releases bioactive peptides called adipokines.

Purpose of the Study:

  • To review the role of adipose tissue-secreted proteins in abdominal obesity.
  • To discuss the regulation of these proteins.
  • To explore their contribution to adverse metabolic consequences.

Main Methods:

  • Literature review of adipose tissue-secreted proteins.
  • Analysis of adipokine roles in metabolic dysfunction.
  • Examination of regulation mechanisms.

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Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
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Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue

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Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
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Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

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Last Updated: Jul 16, 2026

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT
10:30

Whole Body and Regional Quantification of Active Human Brown Adipose Tissue Using 18F-FDG PET/CT

Published on: April 1, 2019

Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue
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Arteriovenous Metabolomics to Measure In Vivo Metabolite Exchange in Brown Adipose Tissue

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Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

Published on: March 17, 2023

Main Results:

  • Adipokines like leptin, TNF-alpha, IL-6, adiponectin, resistin, visfatin, ASP, FIAF, and MT are implicated.
  • These proteins contribute to insulin resistance, endothelial dysfunction, and inflammation.
  • Abdominal obesity is associated with specific adipokine profiles.

Conclusions:

  • Adipokines secreted by adipose tissue play a critical role in metabolic and cardiovascular risk.
  • Understanding adipokine function is crucial for managing obesity-related diseases.
  • Targeting adipokines may offer therapeutic strategies for metabolic disorders.