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Granulomatous meningoencephalomyelitis with peripheral nervous system involvement in a dog

R A Fliegner1, S A Holloway, R F Slocombe

  • 1Department of Veterinary Clinic and Hospital, University of Melbourne, 250 Princes Highway, Werribee VIC 3030.

Australian Veterinary Journal
|March 16, 2007
PubMed

Insights

A Labrador Retriever experienced multifocal neurological disease. Necropsy revealed disseminated granulomatous meningoencephalomyelitis affecting the brain, spinal cord, and peripheral nerves.

Area of Science:

  • Veterinary Neurology
  • Immunopathology

Background:

  • Neurological diseases in dogs can manifest with diverse clinical signs.
  • Accurate diagnosis often requires advanced diagnostics and post-mortem examination.

Observation:

  • A 9-year-old Labrador Retriever presented with multifocal neurological deficits.
  • Cerebrospinal fluid analysis indicated inflammation (mononuclear pleocytosis).
  • Electromyography showed abnormal muscle electrical activity.

Findings:

  • Necropsy confirmed disseminated granulomatous meningoencephalomyelitis (GME).
  • The disease extensively involved the central and peripheral nervous systems.
  • This case highlights GME's potential for widespread neurological impact.

Implications:

  • Early recognition of neurological signs is crucial for veterinary patients.
  • Disseminated GME can lead to severe, progressive neurological dysfunction.
  • Understanding GME's pathology aids in managing canine neurological disorders.

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