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Updated: Jul 16, 2026

Super-Resolution Imaging and Shared Management: A Protocol for Confocal Microscopy with Multiplex Detection
Published on: February 24, 2026
Robust and computationally efficient superresolution algorithm
Kaggere V Suresh1, Ambasamudram N Rajagopalan
1Department of Electrical Engineering, Image Processing and Computer Vision Laboratory, Indian Institute of Technology Madras, Chennai 600036, India.
Abstract:
Superresolution is the process of combining information from multiple subpixel-shifted low-resolution images to form a high-resolution image. It works quite well under ideal conditions but deteriorates rapidly with inaccuracies in motion estimates. We model the original high-resolution image as a Markov random field (MRF) with a discontinuity adaptive regularizer. Given the low-resolution observations, an estimate of the superresolved image is obtained by using the iterated conditional modes (ICM) algorithm, which maximizes the local posterior conditional probability sequentially. The proposed method not only preserves edges but also lends robustness to errors in the estimates of motion and blur parameters. We derive theoretically the neighborhood structure for the posterior distribution in the presence of warping, blurring, and downsampling operations and use this to effectively reduce the overall computations. Results are given on synthetic as well as real data to validate our method.

