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Engineering approaches to biomanipulation.

Jaydev P Desai1, Anand Pillarisetti, Ari D Brooks

  • 1Department of Mechanical Engineering, University of Maryland, College Park, Maryland 20740, USA. jaydev@umd.edu

Annual Review of Biomedical Engineering
|March 17, 2007
PubMed
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This review explores key biomanipulation techniques, including magnetic, MEMS, optical, electric, and mechanical methods, for efficient cell handling. It highlights engineering advances addressing limitations in current cell manipulation systems.

Area of Science:

  • Biotechnology and Bioengineering
  • Cell Biology
  • Microtechnology

Background:

  • Cell manipulation is crucial across various scientific disciplines, including biology and engineering.
  • Conventional cell manipulation methods face challenges that necessitate innovative solutions.
  • Advances in engineering offer new possibilities for efficient biomanipulation systems.

Purpose of the Study:

  • To review and assimilate existing techniques for manipulating biological cells.
  • To focus on key methodologies for developing efficient biomanipulation systems.
  • To discuss the significance and limitations of current biomanipulation approaches.

Main Methods:

  • Review of literature on biomanipulation techniques.
  • Analysis of magnetic, microelectromechanical systems (MEMS)-based, optical, electric field, and mechanical methods.

Related Experiment Videos

  • Assessment of recent engineering advancements impacting cell manipulation.

    • Main Results:

    • Identified key methodologies for efficient cell manipulation: magnetics, MEMS, optics, electric fields, and mechanical techniques.
    • Highlighted how engineering advances are overcoming limitations of conventional methods.
    • Synthesized the significance and limitations of various biomanipulation techniques.

    Conclusions:

    • Multiple advanced techniques offer improved cell manipulation capabilities.
    • Engineering innovations are critical for enhancing the efficiency and addressing challenges in biomanipulation.
    • A comprehensive understanding of technique significance and limitations is vital for future development.