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Related Experiment Video

Updated: Jul 16, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

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Polymorphisms in eosinophil pathway genes, asthma and atopy.

M Kabesch¹, M Depner, I Dahmen

¹University Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany.

|March 17, 2007

Summary

A specific gene variant in the Interleukin-5 (IL-5) gene may protect against atopy and atopic asthma. This finding suggests a genetic link between eosinophil regulation and the development of allergic diseases.

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Published on: April 16, 2019

Area of Science:

Genetics and immunology
Allergy and asthma research

Background:

Eosinophilic inflammation is crucial in asthma development and persistence.
Genetic factors control eosinophil production and survival, prompting investigation into related gene polymorphisms.

Purpose of the Study:

To investigate if polymorphisms in eosinophil regulation pathway genes influence atopic disease development.
Examined genes included IL-3, IL-5, GM-CSF, and their enhancers and receptors.

Main Methods:

Genotyped seven polymorphisms in two large pediatric cohorts (ISAAC II and MAS).
Polymorphisms were located in/around GM-CSF, IL-3, IL-5, IL-5R, and CSFR2b genes.
Statistical analyses included chi-squared tests, variance analyses, and logistic regression for gene-gene interactions.

Main Results:

The T allele at position -746 in the IL-5 gene showed significant protection against atopy in the ISAAC II cohort (P = 0.006).
Carriers of the IL-5 T allele had a decreased risk for atopic asthma (P = 0.036).
Evidence of interaction between the IL-5 polymorphism and a GM-CSF enhancer polymorphism was observed.

Conclusions:

The IL-5 C-746T polymorphism impacts atopic outcomes and demonstrates gene-gene interaction.
No other tested polymorphisms in the eosinophil regulation pathway showed significant associations after multiple testing correction.