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Related Experiment Video

Updated: Jul 16, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Tacrolimus intoxication resolved by gastrointestinal bleeding: case report.

F C Renner¹, A Staak, L Bur Am Orde

¹Renal Transplant Unit, University Clinic of Giessen and Marburg, Giessen, Germany. Fabrice.Renner@innere.med.uni-giessen.de

Transplantation Proceedings

|March 17, 2007

Summary

Severe tacrolimus intoxication in a renal transplant patient was unexpectedly resolved by gastrointestinal bleeding and red blood cell transfusion. This case suggests exchange blood transfusions as a potential treatment for tacrolimus toxicity, especially with impaired liver function.

Related Experiment Videos

Last Updated: Jul 16, 2026

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Quantification of the Immunosuppressant Tacrolimus on Dried Blood Spots Using LC-MS/MS

Published on: November 8, 2015

Area of Science:

Nephrology
Transplantation Medicine
Clinical Pharmacology

Background:

Tacrolimus is a critical immunosuppressant for organ transplant recipients.
Overdosing can lead to serious neurotoxicity.
Standard treatment involves inducing drug-metabolizing enzymes.

Observation:

A 69-year-old renal transplant patient developed acute liver failure, septic shock, and severe tacrolimus intoxication.
The intoxication resolved following a massive gastrointestinal bleed and packed red blood cell transfusion.

Findings:

The patient's tacrolimus levels decreased significantly after the gastrointestinal bleeding and transfusion.
This suggests a mechanism for tacrolimus removal or sequestration by erythrocytes.

Implications:

Exchange blood transfusion may be a viable alternative therapy for severe tacrolimus intoxication.
This approach is particularly relevant in patients with compromised liver function, where standard detoxification methods are less effective.