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Are enteroviral receptors different in sporadic motor neuron disease?

Rebecca B Saunderson1, Bing Yu, Ronald J A Trent

  • 1Department of Pathology, University of Sydney, Sydney, Australia.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
|March 17, 2007
PubMed

Insights

Enteroviruses may contribute to sporadic motor neuron disease (SMND). Researchers found no genetic link between ICAM1 or CAR receptor gene variations and SMND, suggesting these receptors are unlikely to cause the disease.

Area of Science:

  • Neuroscience
  • Virology
  • Genetics

Background:

  • Enteroviruses are implicated in the pathogenesis of sporadic motor neuron disease (SMND).
  • Intercellular adhesion molecule type-1 (ICAM1) and coxsackie and adenovirus receptor (CAR) function as receptors for various enteroviruses.
  • Genetic variations in these receptors could potentially increase susceptibility to enteroviral infections and SMND.

Purpose of the Study:

  • To investigate whether single nucleotide polymorphisms (SNPs) in the viral binding domains of ICAM1 and CAR are associated with sporadic motor neuron disease (SMND).
  • To determine if specific genetic variations in ICAM1 and CAR predispose individuals to enteroviral infections linked to SMND.

Main Methods:

  • Genotyping of single nucleotide polymorphisms (SNPs) within the viral binding domains of ICAM1 and CAR (including adjacent regions and specific exons).
  • Comparison of the distribution of these SNPs between 139 patients with sporadic motor neuron disease (SMND) and 139 matched controls.

Main Results:

  • The distribution of single nucleotide polymorphisms (SNPs) in the examined viral binding domains of ICAM1 and CAR was found to be similar between SMND patients and control groups.
  • Linkage disequilibrium and genotype analysis did not reveal any significant associations.

Conclusions:

  • The genetic analysis suggests that variations in ICAM1 and CAR are unlikely to play a significant role in the pathogenesis of sporadic motor neuron disease (SMND).
  • Further research may be needed to explore other potential enteroviral or host factors involved in SMND.

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