Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Diabetic Ketoacidosis ll: Pathophysiology01:22

Diabetic Ketoacidosis ll: Pathophysiology

Diabetic ketoacidosis (DKA) is a metabolic emergency characterized by hyperglycemia, ketonemia, and metabolic acidosis. It results from severe insulin deficiency and an excess of counterregulatory hormones, leading to uncontrolled lipolysis, ketogenesis, and widespread electrolyte and fluid disturbances.Pathophysiology The central event in DKA is a profound loss of insulin action. Without insulin, glucose uptake in insulin-dependent tissues is impaired, while hepatic glucose production...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Aprotinin for patients exposed to clopidogrel before off-pump coronary bypass.

Asian cardiovascular & thoracic annals·2008
Same author

False aneurysm of the left ventricle following myocardial infarction: an unusual location.

Cardiovascular journal of Africa·2007
Same author

Impact of clopidogrel on postoperative blood loss after non-elective coronary bypass surgery.

Interactive cardiovascular and thoracic surgery·2007
Same author

Association of edge-to-edge repair to De Vega annuloplasty for tricuspid incompetence.

Scandinavian cardiovascular journal : SCJ·2007
Same author

Coronary by-pass for bad ventricle; adoption of "hybrid-pump" bypass.

Journal of cardiothoracic surgery·2006
Same author

Off-pump coronary bypass for patients with concomitant malignancy.

Circulation journal : official journal of the Japanese Circulation Society·2006

Related Experiment Video

Updated: Jul 16, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Off-pump CABG in diabetic patients: does insulin dependency matter?

Feza Nurozler1, Tolga Kutlu, Güngör Küçük

  • 1Division of Cardiovascular Surgery, Central Hospital, Izmir, Turkey. fnurozler@yahoo.com

Scandinavian Cardiovascular Journal : SCJ
|March 17, 2007
PubMed
Summary

Insulin-dependent diabetes patients experienced more postoperative complications, including stroke and wound infections, after off-pump CABG surgery. They also had longer intensive care unit stays compared to non-insulin-dependent diabetic patients.

Related Experiment Videos

Last Updated: Jul 16, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

Area of Science:

  • Cardiovascular Surgery
  • Diabetology
  • Intensive Care Medicine

Background:

  • Diabetes mellitus is a significant comorbidity in patients undergoing coronary artery bypass grafting (CABG).
  • Insulin dependency in diabetic patients may influence surgical outcomes.
  • Off-pump coronary artery bypass grafting (OPCAB) is a surgical technique with specific patient considerations.

Purpose of the Study:

  • To analyze the influence of insulin dependency on short-term outcomes after OPCAB in patients with diabetes.
  • To compare postoperative complication rates and hospital stay between insulin-dependent and non-insulin-dependent diabetic patients undergoing OPCAB.

Main Methods:

  • Retrospective cohort study involving 148 diabetic patients undergoing OPCAB.
  • Patients were divided into two groups: insulin-dependent (Group I) and non-insulin-dependent (Group II).
  • Analysis of preoperative data, in-hospital mortality, major and minor postoperative complications, and duration of intensive care unit (ICU) and hospital stay.

Main Results:

  • No significant difference in in-hospital mortality between groups.
  • Insulin-dependent diabetics had a higher incidence of stroke (p=0.027), sternal wound infection (p=0.036), and atrial arrhythmia (p=0.021).
  • Group I patients showed a trend towards higher renal dysfunction (p=0.069) and significantly longer ICU stays (p=0.038).

Conclusions:

  • Insulin dependency is associated with an increased risk of major postoperative complications after OPCAB.
  • Diabetic patients requiring insulin have longer ICU durations following OPCAB.
  • These findings suggest careful perioperative management is crucial for insulin-dependent diabetics undergoing OPCAB.