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Infective endocarditis caused by daptomycin-resistant Enterococcus faecalis: a case report.

Zeina A Kanafani1, Jerome J Federspiel, Vance G Fowler

  • 1Division of Infectious Diseases, Duke University Medical Center, Durham, NC 27710, USA.

Scandinavian Journal of Infectious Diseases
|March 17, 2007
PubMed
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Daptomycin resistance is emerging in Enterococcus faecalis infections. This study reports the second known case of daptomycin-resistant Enterococcus faecalis, highlighting a growing clinical challenge.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Daptomycin is a crucial lipopeptide antibiotic for treating Gram-positive bacterial infections.
  • Enterococcus faecalis is a common cause of hospital-acquired infections.

Observation:

  • This study details the second documented instance of daptomycin resistance in a clinical Enterococcus faecalis isolate.
  • The isolate exhibited reduced susceptibility to daptomycin, a critical antibiotic.

Findings:

  • The emergence of daptomycin resistance in Enterococcus faecalis poses a significant therapeutic challenge.
  • This finding underscores the need for vigilant monitoring of antibiotic susceptibility.

Implications:

Related Experiment Videos

  • Clinical management of Gram-positive infections may require alternative treatment strategies.
  • Further research into the mechanisms of daptomycin resistance is essential.