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Plasma platelet-derived growth factor levels in coronary circulation in unstable angina pectoris
Insights
Plasma platelet-derived growth factor (PDGF) is elevated in the coronary circulation of unstable angina patients. This finding suggests increased PDGF release contributes to unstable angina progression.
Area of Science:
- Cardiology
- Biochemistry
- Medical Science
Background:
- Platelet-derived growth factor (PDGF) plays a role in cardiovascular disease.
- Unstable angina is a critical condition requiring understanding of underlying mechanisms.
Purpose of the Study:
- To investigate if plasma platelet-derived growth factor (PDGF) levels are elevated in the coronary circulation of patients with unstable angina.
- To compare PDGF levels in patients with unstable angina, stable exertional angina, and control subjects.
Main Methods:
- Simultaneous measurement of plasma PDGF levels in the coronary sinus and aortic root.
- Inclusion of 14 patients with unstable angina, 15 with stable exertional angina, and 15 control subjects.
Main Results:
- Mean plasma PDGF levels in the coronary sinus were significantly higher in unstable angina patients compared to stable angina and control groups (p < 0.01).
- No significant differences in plasma PDGF levels were observed in the aortic root among the three groups.
Conclusions:
- PDGF release is increased in the coronary circulation of patients experiencing unstable angina.
- Elevated coronary PDGF may be a contributing factor to the pathophysiology of unstable angina.
Abstract:
To examine whether plasma platelet-derived growth factor (PDGF) levels are elevated in the coronary circulation of patients with unstable angina, the plasma PDGF levels in the coronary sinus and aortic root were simultaneously examined in 14 patients with unstable angina, 15 with stable exertional angina, and 15 control subjects. The mean plasma PDGF level (pg/ml) in the coronary sinus was significantly higher (p less than 0.01) in patients with unstable angina than in those with stable exertional angina and in control subjects (502.1 +/- 98.7 vs 301.3 +/- 62.5, and 312.7 +/- 62.6). However, there were no significant differences in mean plasma PDGF levels in the aortic root among the 3 groups. It is concluded that PDGF release is increased in the coronary circulation in patients with unstable angina.