[Serum IL-12 level in mice infected with Trichinella spiralis]

Kunming mice were infected by feeding 150+/-5 larvae of Trichinella spiralis, established was also a normal control group. Blood was collected from the ophthalmic venous plexus respectively on 7 d, 21 d, 35 d and 49 d after infection and IL-12 in the serum was detected by ELISA. The level of IL-12 in serum decreased in groups of 7 d, 21 d, and 35 d, with a significant difference to the control (P<0.01). However, there was no significant difference between 49d group and control (P>0.05), suggesting that the serum IL-12 of the Trichinella spiralis-infected mice significantly decreased at the earlier stage but approached to normal at a later stage.