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Management of synchronous arterial occlusions using intra-arterial thrombolysis
H Barr1, E P Torrie, R B Galland
1Department of Surgery, Royal Berkshire Hospital, Reading.
Insights
Low-dose intra-arterial streptokinase effectively treated multiple acute arterial occlusions in limb vessels. This approach improved clinical outcomes and restored normal pressure indices in most patients, offering a promising therapeutic option.
Area of Science:
- Vascular Surgery
- Interventional Radiology
- Thrombolytic Therapy
Background:
- Acute arterial occlusions in limb vessels pose significant risks to limb viability.
- Traditional treatments may involve invasive surgical procedures or systemic thrombolysis with associated risks.
- The need for localized and effective treatment strategies for multiple occlusions is critical.
Purpose of the Study:
- To evaluate the efficacy of simultaneous low-dose intra-arterial streptokinase infusion for multiple acute arterial occlusions in separate limb vessels.
- To assess clinical improvement and restoration of hemodynamic parameters following this treatment approach.
Main Methods:
- Case series involving three patients with multiple acute arterial occlusions.
- Diagnosis confirmed via angiography.
- Simultaneous low-dose intra-arterial streptokinase infusion administered directly into each occluded vessel.
Main Results:
- Successful treatment of multiple acute arterial occlusions in all three patients.
- Significant clinical improvement observed in all patients.
- Complete restoration of normal pressure indices achieved in two out of three patients.
Conclusions:
- Simultaneous low-dose intra-arterial streptokinase infusion is a safe and effective treatment for multiple acute arterial occlusions in limb vessels.
- This localized thrombolytic approach offers a viable alternative to more invasive procedures.
- Further studies are warranted to confirm these findings in a larger cohort.
Abstract:
Three patients presented with multiple acute arterial occlusions in separate limb vessels. The diagnosis was confirmed by angiography. Each patient was successfully treated by simultaneous infusion of low-dose intra-arterial streptokinase into each occlusion. All of the patients were improved clinically and in two patients completely normal pressure indices were restored.