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Detection of Antibodies That Neutralize the Cellular Uptake of Enzyme Replacement Therapies with a Cell-based Assay
Published on: September 10, 2018
Anti-oxidant strategies.
Giuseppe Buonocore1, Floris Groenendaal
1Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, viale Bracci 36, Siena, Italy. buonocore@unisi.it
Seminars in Fetal & Neonatal Medicine
|March 21, 2007
Summary
Oxidative stress contributes to organ injury in fetuses and neonates. Antioxidant therapies show promise for neuroprotection against perinatal oxidative stress and cerebral damage.
Area of Science:
- Perinatal medicine
- Neuroscience
- Biochemistry
Background:
- Oxidative stress is a significant factor in organ damage in compromised fetuses and neonates.
- Reactive oxygen and nitrogen species production pathways are increasingly understood.
- Free radicals contribute to cerebral damage following perinatal hypoxia-ischemia.
Purpose of the Study:
- To review the role of oxidative stress in fetal and neonatal organ injury.
- To discuss the potential of antioxidant strategies as neuroprotective therapies.
Main Methods:
- Review of experimental research and clinical studies.
- Analysis of pathways involved in reactive oxygen and nitrogen species production.
- Identification of potential antioxidant compounds for clinical trials.
Main Results:
- Oxidative stress mechanisms in perinatal hypoxia-ischemia are clarified.
- Free radicals damage lipids, proteins, and DNA, leading to cerebral damage.
- Several antioxidant compounds show promise for neuroprotection.
Conclusions:
- Antioxidant strategies represent a viable add-on neuroprotective therapy for perinatal oxidative stress.
- Selective inhibitors of nitric oxide synthase, allopurinol, melatonin, and erythropoietin are candidates for clinical trials.
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