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Cutaneous infiltration by cancer.
Joaquim Marcoval1, Abelardo Moreno, Jordi Peyrí
1Department of Dermatology, Hospital de Bellvitge, IDIBELL, University of Barcelona, Barcelona, Spain. jmarcoval@csub.scs.es
Journal of the American Academy of Dermatology
|March 21, 2007
Summary
Cutaneous cancer infiltration, often a late sign, was analyzed in 381 patients. Breast carcinoma was most common, with skin lesions appearing at initial diagnosis in over a third of cases.
Area of Science:
- Oncology
- Dermatopathology
- Clinical Medicine
Background:
- Cutaneous infiltration by cancer occurs in 0.7%-9% of patients with malignant neoplasms.
- It is typically a late-stage event in visceral carcinomas.
Purpose of the Study:
- To analyze the clinicopathological features of cutaneous infiltration by cancer.
- To evaluate the significance of skin lesions in cancer diagnosis and management.
Main Methods:
- Retrospective review of 381 biopsy specimens (1988-2005) of cutaneous infiltration by cancer.
- Exclusion of patients with hematologic malignancies.
- Review of clinical charts for additional patient data.
Main Results:
- Breast carcinoma (168 cases) was the most frequent primary tumor, followed by malignant melanoma (59 cases).
- Solitary nodules (153 cases) were the most common presentation.
- Cutaneous infiltrative lesions were present at the primary tumor diagnosis in 33.6% of patients.
Conclusions:
- Cutaneous biopsy is increasingly important for managing oncology patients, especially in breast carcinoma.
- Prognostic factors can be determined by analyzing malignant tumor tissue samples.
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