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Updated: Jul 16, 2026
Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
Published on: June 1, 2012
Immobilization and long-term culturing of mouse embryonic stem cells in collagen-chitosan gel matrix
I I Selezneva1, I V Savintseva, E F Vikhlyantseva
1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino. selezneva_i@mail.ru
Abstract:
We propose a method of creation of a 3D matrix consisting of native collagen fibers and natural polysaccharide chitosan. The collagen-chitosan hydrogels maintain viability and prolipherative activity of embryonic stem cells obtained from internal cells of mouse blastocyst. The proposed system forming hydrogels in situ can be used in cell therapy for immobilization and targeted delivery of stem cells.
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