Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cognitive function, P3a/P3b brain potentials, and cortical thickness in aging.

Anders M Fjell1, Kristine B Walhovd, Bruce Fischl

  • 1Department of Psychology, University of Oslo, Norway. a.m.fjell@psykologi.uio.no

Human Brain Mapping
|March 21, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stable individual differences dominate adult brain volume variation until later life.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Failure to detect entorhinal grid-like signals in a passive navigation human fMRI study.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Unwrapping the mirror tracing task.

Behavior research methods·2026
Same author

Differential expression of spatiotemporal sleep spindle clusters in aging.

Sleep advances : a journal of the Sleep Research Society·2025
Same author

Public Health.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2025
Same author

Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden.

NeuroImage. Clinical·2025
Same journal

Benchmarking fMRI Denoising Pipelines.

Human brain mapping·2026
Same journal

Modeled Long-Term Effects of Psilocybin on Dynamic Activity and Effective Connectivity of Fronto-Striatal-Thalamic Circuits.

Human brain mapping·2026
Same journal

Intrinsic Functional Architecture Reflects Individual Differences in Passive Working Memory: An Exploratory Resting-State fMRI Study.

Human brain mapping·2026
Same journal

Symptom Overlap and Neurobiological Similarities Between Posttraumatic Stress Disorder and Tinnitus.

Human brain mapping·2026
Same journal

Test-Retest Reliability of Sensorimotor Activity Measured With Spinal Cord fMRI.

Human brain mapping·2026
Same journal

The Human Visual Claustrum Responses to Physical Stimulus Properties and Subjective Content During Movie Viewing.

Human brain mapping·2026
See all related articles

Brain potential (P3a/P3b) and cortical thickness are linked to cognitive function in older adults. This relationship is specific to certain brain regions and is not solely explained by age.

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Aging is associated with changes in brain structure and function.
  • Event-related potentials (ERPs), such as P3a and P3b, reflect cognitive processing.
  • Cortical thickness is a measure of brain structure that can change with age.

Purpose of the Study:

  • To investigate the relationship between P3a/P3b brain potentials, cortical thickness, and cognitive function in aging.
  • To explore how age influences these relationships.
  • To identify specific cortical regions involved in these associations.

Main Methods:

  • Thirty-five younger and 37 older healthy adults participated.
  • Participants underwent a visual oddball ERP task, neuropsychological testing, and MRI scans.

Related Experiment Videos

  • Cortical thickness was analyzed across the entire brain, and P3a/P3b potentials were measured.

    • Main Results:

    • In older adults, P3a amplitude was associated with cortical thickness in parietal and posterior cingulate areas.
    • P3b latency was linked to cortical thickness in frontal regions in the elderly.
    • Path models revealed that temporoparietal cortical thickness predicted P3a amplitude and executive function; orbitofrontal thickness predicted P3b latency and fluid function.

    Conclusions:

    • Cortical thickness in specific brain regions correlates with P3a/P3b potentials in older adults.
    • These structural-functional relationships partially mediate cognitive functions like executive and fluid abilities.
    • The direct link between P3 and cognition diminishes when age is accounted for, highlighting the role of cortical thickness.