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Updated: Jul 16, 2026

Single-Molecule Diffusion and Assembly on Polymer-Crowded Lipid Membranes
Published on: July 19, 2022
Interaction of DNA oligomers with cationic lipidic monolayers: complexation and splitting
Svetlana Erokhina1, Tatiana Berzina, Luigi Cristofolini
1Department of Physics, University of Parma, Viale Usberti 7 A, 43100 Parma, Italy. erokhin@fis.unipr.it
Abstract:
Interactions of native DNA with octadecylamine (ODA) and hexadecymdimethylammonium bromide (HTAB) monolayers at the air/water interface were studied by pi-A isotherms, ellipsometry, and X-ray reflectivity. We show that the microscopic structure of ODA-DNA complexes is definitely consistent with a single-stranded form for DNA. On the contrary, with HTAB, DNA complexes in its native form. The crucial difference in the behavior of these two fairly similar lipids is due to the presence of the amine group in ODA. These results should be relevant to applications such as DNA chips and sensors.
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