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Sense-antisense pairs in mammals: functional and evolutionary considerations

Pedro A F Galante1, Daniel O Vidal, Jorge E de Souza

  • 1Ludwig Institute for Cancer Research, São Paulo Branch, Hospital Alemão Oswaldo Cruz, São Paulo, SP, Brazil. pgalante@compbio.ludwig.org.br

Genome Biology
|March 21, 2007
PubMed
Summary

Natural antisense transcripts (NATs) play roles in cellular processes, but many are artifacts from cDNA library construction. A new model explains the origin of functional sense-antisense (S-AS) pairs in mammalian genomes.

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