Related Experiment Video

Updated: Jul 16, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
08:31

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions

Published on: December 1, 2020

Mebendazole selective membrane sensor and its application to pharmaceutical analysis

K Girish Kumar1, Sareena John, Pearl Augustine

  • 1Department of Applied Chemistry, Cochin University of Science and Technology, Kochi, India. giri@cusat.ac.in

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
|March 21, 2007
PubMed

Insights

A new PVC membrane sensor selectively detects mebendazole (MBZ) using silicotungstic acid. This cost-effective sensor offers a wide linear range and high selectivity for MBZ determination in pharmaceuticals.

Area of Science:

  • Analytical Chemistry
  • Materials Science

Background:

  • Mebendazole (MBZ) is an important anthelmintic drug.
  • Accurate and selective determination of MBZ is crucial for pharmaceutical quality control.

Purpose of the Study:

  • To develop a novel PVC membrane sensor for the selective determination of mebendazole (MBZ).
  • To investigate the sensor's performance characteristics, including linearity, response time, and selectivity.
  • To evaluate the sensor's applicability for MBZ determination in pharmaceutical formulations.

Main Methods:

  • Fabrication of a PVC membrane sensor incorporating an ion association of MBZ with silicotungstic acid (STA) and bis(2-ethylhexyl)phthalate (BEP) as the plasticizer.
  • Electrochemical characterization of the sensor, including potentiometric measurements.
  • Testing sensor response across a range of MBZ concentrations and pH values.
  • Selectivity studies against common interfering ions.
  • Analysis of MBZ in pharmaceutical samples.

Main Results:

  • The sensor exhibited a linear response for MBZ over a wide concentration range (1.0x10(-6)-5.0x10(-2) M).
  • A Nernstian slope of 55.8 mV/decade was achieved with a low limit of detection (6.3x10(-7) M) in the pH range of 4-7.
  • The sensor demonstrated a fast response time (<30 s) and excellent selectivity for MBZ against various ions.
  • Direct determination of MBZ in pharmaceutical formulations yielded results comparable to standard methods.

Conclusions:

  • The developed PVC membrane sensor provides a selective, sensitive, and rapid method for mebendazole determination.
  • The sensor's performance and applicability in pharmaceutical analysis highlight its potential for quality control.

More Related Videos

ELIME (Enzyme Linked Immuno Magnetic Electrochemical) Method for Mycotoxin Detection12:11

ELIME (Enzyme Linked Immuno Magnetic Electrochemical) Method for Mycotoxin Detection

Published on: October 23, 2009

Extraction and Detection of Geosmin and 2-Methylisoborneol in Water and Fish using High-Capacity Sorptive Extraction Probes and GC-MS11:59

Extraction and Detection of Geosmin and 2-Methylisoborneol in Water and Fish using High-Capacity Sorptive Extraction Probes and GC-MS

Published on: July 3, 2025

Related Concept Videos

Microbial Biosensors01:17

Microbial Biosensors

Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...
Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Potentiometry: Membrane Electrodes01:15

Potentiometry: Membrane Electrodes

Membrane electrodes, also known as p-ion electrodes, use membranes that selectively interact with free analyte ions, generating a potential difference across the membrane. The resulting membrane potential, known as the asymmetry potential, is not zero even when analyte concentrations on both sides of the membrane are equal. The membrane's response is typically not selective to a single analyte but proportional to the concentration of all ions in the sample solution capable of interacting at the...