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Updated: Jul 16, 2026

An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
[Hepatitis c virus and type 2 diabetes mellitus]
V Guglielmi1, M Tutino, V Guerra
1Unità Operativa Complessa di Gastroenterologia ed Endoscopia Digestiva, IRCCS S. De Bellis, Castellana Grotte, BA, Italy. vitantonioguglielmi@tiscali.it
Aim:
In literature there are many reports on hepatitis C virus (HCV) and type 2 diabetes mellitus association. However, many authors have proved this association in anti-HCV positive patients affected by cirrhosis. Thus, type 2 diabetes mellitus has been associated to cirrhosis rather than to HCV.
Methods:
We wanted to verify the type 2 diabetes mellitus prevalence in 3 606 anti-HCV positive patients both cirrhotic and noncirrhotic. The results obtained have been compared with those of 1 053 HBsAg positive patients. All the patients were hospitalised for the first time in our institute between January 1991 and December 2003.
Results:
Type 2 diabetes mellitus is more frequently associated to cirrhotic rather than to noncirrhotic patients, but between the 2 groups of patients (anti-HCV and HBsAg positive) HCV increases type 2 diabetes mellitus association significantly.
Conclusions:
Hepatic cirrhosis and HCV make easier the onset of type 2 diabetes mellitus.
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