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Updated: Jul 16, 2026
10:17
An Advanced Murine Model for Nonalcoholic Steatohepatitis in Association with Type 2 Diabetes
Published on: April 26, 2019
[Hepatitis c virus and type 2 diabetes mellitus]
V Guglielmi1, M Tutino, V Guerra
1Unità Operativa Complessa di Gastroenterologia ed Endoscopia Digestiva, IRCCS S. De Bellis, Castellana Grotte, BA, Italy. vitantonioguglielmi@tiscali.it
Minerva Medica
|March 21, 2007
Summary
Hepatitis C virus (HCV) and hepatic cirrhosis significantly increase the risk of developing type 2 diabetes mellitus. This study confirms HCV
Area of Science:
- Hepatology
- Virology
- Endocrinology
Context:
- The association between Hepatitis C Virus (HCV) infection and type 2 diabetes mellitus (T2DM) is frequently reported.
- Previous studies often linked T2DM to cirrhosis in HCV-positive patients, obscuring the direct role of HCV.
- This research investigates T2DM prevalence in HCV-positive individuals, considering both cirrhotic and non-cirrhotic patients.
Purpose:
- To determine the prevalence of type 2 diabetes mellitus in a large cohort of anti-HCV positive patients.
- To compare T2DM association in HCV-positive patients with HBsAg-positive patients.
- To clarify whether HCV or cirrhosis is more strongly associated with T2DM.
Summary:
- A study of 3,606 anti-HCV positive patients and 1,053 HBsAg positive patients revealed T2DM is more common in cirrhotic individuals.
- However, the analysis demonstrated that Hepatitis C Virus significantly increases the likelihood of T2DM, independent of cirrhosis.
- HCV infection is a significant risk factor for developing type 2 diabetes mellitus.
Impact:
- Highlights Hepatitis C Virus as a direct contributor to type 2 diabetes mellitus development.
- Suggests screening for T2DM in all HCV-positive patients, regardless of liver disease severity.
- Informs clinical management and public health strategies for managing comorbidities in viral hepatitis.
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