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Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors
Published on: May 9, 2025
A quantitative structure-activity relationship study on matrix metalloproteinase inhibitors: piperidine sulfonamide
1Department of Pharmacy, Birla Institute of Technology and Science, Pilani-333031, India.
Journal of Enzyme Inhibition and Medicinal Chemistry
|March 22, 2007
Abstract:
A quantitative structure-activity relationship (QSAR) study has been made on a series of piperidine sulfonamide aryl hydroxamic acid analogs acting as matrix metalloproteinase (MMP) inhibitors. The inhibitory potencies of the compounds against two MMPs, MMP-2 and MMP-13, are found to be significantly correlated with the hydrophobic properties of the molecules, suggesting that in both enzymes the hydrophobic interaction is playing a dominant role.

