Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Automated ion channel screening: patch clamping made easy.

Cecilia Farre1, Sonja Stoelzle, Claudia Haarmann

  • 1Nanion Technologies GmbH, Erzgiessereistr. 4, 80335 Munich, Germany.

Expert Opinion on Therapeutic Targets
|March 22, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Recognition to repair: Managing reservoir complications in inflatable penile prosthesis surgery.

BJUI compass·2026
Same author

Variation in emergency department attendances and acute hospital admissions for ambulatory emergency care: a retrospective analysis of routinely collected NHS data across England.

BMJ open·2026
Same author

Resolving three GABA induced electrogenic events and GABA-coupling stoichiometry for Na<sup>+</sup> and Cl<sup>-</sup> in hGAT-1.

The FEBS journal·2026
Same author

The contemporary academic landscape of penile prosthesis surgery: a bibliometric analysis.

The journal of sexual medicine·2026
Same author

Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons.

Neurobiology of pain (Cambridge, Mass.)·2026
Same author

A fast and semi-fragile high-capacity digital watermarking system for MRI images using a hybrid combination of DOST and LBP features.

Scientific reports·2026

Automated patch clamping offers high-resolution ion channel recordings with increased efficiency for drug discovery. This chip-based technology provides reliable data without extensive training, advancing ion channel research.

Area of Science:

  • Electrophysiology
  • Pharmacology
  • Biophysics

Background:

  • The conventional patch clamp technique provides high-resolution ion channel data but is inefficient.
  • There is a need for high-throughput, high-resolution techniques for ion channel screening and research.
  • Automated patch clamping addresses these limitations.

Purpose of the Study:

  • To describe chip-based patch clamp technology.
  • To highlight its utility in ion channel drug screening and academic research.
  • To present Nanion's Port-a-Patch and Patchliner as advanced automated patch clamp platforms.

Main Methods:

  • Utilized chip-based technology for automated patch clamping.
  • Employed Nanion's Port-a-Patch and Patchliner workstations.

Related Experiment Videos

  • Achieved high-quality patch clamp recordings with giga-seal formation and stable signals.

    • Main Results:

    • Demonstrated high-quality, stable patch clamp recordings via automated systems.
    • Showcased accessibility of advanced techniques without prolonged training.
    • Highlighted capabilities for rapid ligand application, temperature control, and internal solution exchange.

    Conclusions:

    • Automated patch clamping platforms provide efficient, high-resolution ion channel analysis.
    • This technology facilitates drug discovery and novel experimental approaches in ion channel research.
    • Chip-based systems offer sophisticated electrophysiological capabilities for both industry and academia.