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Published on: August 2, 2018
[Expression and significance of hypoxia inducible factor-1alpha in buccal carcinoma]
Bo Han1, Long-jiang Li, Wei Dai
1Dept. of Head and Neck Tumor Surgery, West China College of Stomatology, Sichuan University, Chengdu, China.
Objective:
To study the expression of hypoxia inducible factor-1alpha (HIF-1alpha) protein in buccal carcinoma and its biological significance.
Methods:
The expression of HIF-1alpha was assayed by means of immunohistochemical technique in 60 patients. The expression of HIF-1alpha and its relationship with clinical pathological factors and tumor prognosis were investigated and analyzed statistically by Kruskal-Wallis Test.
Results:
The positive rate of HIF-1alpha was higher in T3-4 than T1-2, and the positive rate of HIF-1alpha was higher in patients with cervical lymphatic metastasis than patients without cervical lymphatic metastasis. Patients with HIF-1alpha over-expression had poor prognosis than patients with HIF-1alpha lower expression.
Conclusion:
Over-expression of HIF-1alpha is a vital biological marker in prognosis of buccal cancer.
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