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Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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Related Experiment Video

Updated: Jul 16, 2026

Behavioral Characterization of an Angelman Syndrome Mouse Model

Behavioral Characterization of an Angelman Syndrome Mouse Model

Published on: October 20, 2023

Building different mouse models for human MS.

Estelle Bettelli¹

¹Center for Neurologic Diseases, Brigham and Womens Hospital, Boston MA 02115, USA. ebettelli@rics.bwh.harvard.edu

Annals of the New York Academy of Sciences

|March 23, 2007

Summary

This study investigates mouse models of multiple sclerosis (MS) to understand its diverse forms. Findings reveal distinct inflammatory patterns in optic neuritis and Devic's disease, offering insights into MS pathogenesis.

Area of Science:

Neuroimmunology
Central Nervous System (CNS) Disorders

Background:

Multiple sclerosis (MS) is a heterogeneous inflammatory CNS disease.
Optic neuritis is a common initial symptom of MS.
Devic's disease (neuromyelitis optica) primarily affects optic nerves and spinal cord.

Purpose of the Study:

To explore the immunological basis of different MS forms.
To characterize mouse models mimicking human MS variants.

Main Methods:

Utilized 2D2 T cell receptor (TCR) transgenic mice specific for myelin oligodendrocyte glycoprotein (MOG).
Developed a second model by crossing 2D2 mice with MOG-specific IgH knockin (TH) mice.
Analyzed spontaneous development of optic neuritis and experimental autoimmune encephalomyelitis (EAE).

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Main Results:

2D2 mice spontaneously developed isolated optic neuritis.
The crossed 2D2 x TH mice developed severe EAE with lesions mimicking Devic's disease.
Lesions were selectively distributed in the spinal cord and optic nerves.

Conclusions:

These mouse models replicate distinct human MS pathologies.
The findings provide insights into the immunological mechanisms underlying MS heterogeneity.
Further research into these models can elucidate MS pathogenesis.