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Urinary mineral excretion in preterm neonates during the first month of life

Vasileios I Giapros1, Athanasios L Papaloukas, Styliani K Andronikou

  • 1Neonatal Intensive Care Unit, Child Health Department, University of Ioannina, Ioannina, Greece. vgiapros@cc.uoi.gr

Neonatology
|March 23, 2007
PubMed

Insights

Urinary excretion of calcium, phosphate, and magnesium remains stable in preterm infants fed formula during their first month of life. However, urinary calcium, sodium, and magnesium levels show close correlations during this period.

Area of Science:

  • Neonatal Medicine
  • Pediatric Nephrology
  • Biochemistry

Background:

  • Urinary parameter estimation aids in identifying metabolic derangements in preterm infants.
  • Monitoring renal excretion is crucial for understanding mineral balance in vulnerable neonates.

Purpose of the Study:

  • To examine the variability and associations in renal excretion of calcium, magnesium, phosphate, and sodium.
  • To assess these parameters in formula-fed preterm infants during the first month of life.

Main Methods:

  • A prospective, longitudinal study of 34 preterm infants (<32 weeks gestational age).
  • Serum and 8-hour urine mineral and creatinine concentrations were measured at three time points.
  • Calculated urinary parameters included fractional excretion of sodium (FENa) and phosphate (FEP), and urinary calcium/creatinine (UCa/UCr) and magnesium/creatinine (UMg/UCr) ratios.

Main Results:

  • Urinary excretion of calcium, phosphate, and magnesium remained stable throughout the first month.
  • Sodium excretion showed a decline over the study period.
  • Significant positive correlations were found between the excretion of calcium, magnesium, and sodium.

Conclusions:

  • Urinary excretion of calcium, phosphate, and magnesium is stable in preterm formula-fed infants in the first month of life.
  • Urinary calcium, sodium, and magnesium levels are closely correlated during this neonatal period.
Abstract

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