Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Alterations in Blood Pressure01:30

Alterations in Blood Pressure

Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart beats)...
Antihypertensive Drugs: Thiazide-Class Diuretics01:15

Antihypertensive Drugs: Thiazide-Class Diuretics

Thiazide diuretics are sulfonamide derivatives featuring a benzothiadiazine ring system in their molecular structure. Based on this structure, thiazide diuretics can be categorized into two groups: thiazide-type and thiazide-like diuretics. Thiazide-type diuretics, including hydrochlorothiazide and chlorothiazide, consist of a benzothiadiazine backbone with an attached sulfonamide group. Thiazide-like diuretics, such as chlorthalidone and indapamide, lack the thiazide ring but demonstrate...
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Antihypertensive Drugs: Action of Diuretics01:16

Antihypertensive Drugs: Action of Diuretics

Diuretics are antihypertensive drugs used to treat hypertension resulting from sodium and water retention. Sodium, vital for fluid balance and nerve or muscle function, is regulated by the kidneys through millions of nephrons. Blood enters nephrons via afferent arterioles, which branch into capillaries called glomeruli. These filter blood plasma, allowing water and solutes, like sodium ions, to pass through capillary walls into Bowman's capsule. The filtrate then flows through various tubules...
Hypertension V: Nursing Management01:23

Hypertension V: Nursing Management

The nursing management of hypertension involves accurately assessing symptoms, making a comprehensive nursing diagnosis, collaborating with patients to set goals, and implementing targeted interventions to mitigate the condition's impact and improve patient well-being.Comprehensive AssessmentThe initial step in nursing care for hypertension involves a thorough patient assessment. It includes evaluating symptoms such as headaches, dizziness, blurred vision, and previous hypertension episodes.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Developmental trajectories of vocal behaviors in common marmosets as a reference framework for neurobehavioral studies.

Frontiers in neural circuits·2026
Same author

Homocysteine increases phosphorylation and aggregation of α-synuclein.

Journal of clinical biochemistry and nutrition·2026
Same author

Fibroblastic and myofibroblastic differentiation of cutaneous pleomorphic sarcomas in rabbits.

The Journal of veterinary medical science·2026
Same author

PRDX4 Potentially Serves as an Independent Marker for Early Recurrence of Oral Squamous Cell Carcinoma.

Anticancer research·2026
Same author

Combined assessment of stromal tumor infiltrating lymphocytes and tumor peroxiredoxin 4 expression improved prognostic stratification in postoperative pancreatic cancer patients.

Diagnostic pathology·2026
Same author

Systemic apolipoprotein C-III amyloidosis in an Asian lion (Panthera leo persica).

The Journal of veterinary medical science·2026

Related Experiment Video

Updated: Jul 16, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly inpatients: effects of

Shigeto Morimoto1, Takashi Takahashi, Kohya Okaishi

  • 1Department of Geriatric Medicine, Kanazawa Medical University, Ishikawa, Japan. shigeto@kanazawa-med.ac.jp

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|March 24, 2007
PubMed
Summary

Elderly hypertensive patients, especially those bedridden, experience significant blood pressure drops when changing posture. Azelnidipine treatment effectively reduces this effect and improves pulse rate response.

Related Experiment Videos

Last Updated: Jul 16, 2026

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance
14:09

Tilt Testing with Combined Lower Body Negative Pressure: a "Gold Standard" for Measuring Orthostatic Tolerance

Published on: March 21, 2013

Area of Science:

  • Gerontology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Postural changes can significantly impact blood pressure (BP) in elderly individuals.
  • Hypertensive patients, particularly those who are bedridden, may be more susceptible to BP variability.
  • Understanding these changes is crucial for managing cardiovascular health in the elderly.

Purpose of the Study:

  • To investigate blood pressure variability in elderly hypertensive patients during postural changes.
  • To evaluate the effect of azelnidipine on tilt-induced BP changes in bedridden hypertensive patients.

Main Methods:

  • A study involving 154 elderly inpatients (hypertensive and normotensive, bedridden and non-bedridden).
  • Blood pressure and pulse rate were measured in supine and head-up tilt positions (45 degrees).
  • Hypertensive patients received 3-month monotherapy with azelnidipine.

Main Results:

  • Bedridden hypertensive patients showed a significantly greater decrease in systolic blood pressure (SBP) upon tilting compared to other groups.
  • Azelnidipine treatment significantly reduced basal BP and pulse rate.
  • Azelnidipine attenuated the tilt-induced SBP decrease and enhanced pulse rate response in bedridden hypertensive patients.

Conclusions:

  • Tilt-induced SBP decrease is common in bedridden elderly hypertensive patients.
  • Azelnidipine treatment effectively mitigates postural BP changes in this population.
  • Azelnidipine may improve baroreceptor sensitivity, contributing to its beneficial effects.