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Pelvi-ureteric junction obstruction in children: the role of urinary transforming growth factor-beta and epidermal

Mohamed A Taha1, Ahmed A Shokeir, Hussein G Osman

  • 1Mansoura Urology and Nephrology Centre and Department of Biochemistry, Faculty of Science, Mansoura University, Mansoura, Egypt.

BJU International
|March 24, 2007
PubMed

Insights

Urinary transforming growth factor beta(1) (TGF-beta(1)) shows promise for monitoring children with pelvi-ureteric junction obstruction (PUJO) post-surgery. Epidermal growth factor (EGF) is not recommended for diagnosis in these cases.

Area of Science:

  • Pediatric Urology
  • Biomarker Discovery
  • Nephrology

Background:

  • Pelvi-ureteric junction obstruction (PUJO) is a common congenital anomaly in children.
  • Noninvasive diagnostic and follow-up tools for PUJO are crucial for effective management.

Purpose of the Study:

  • To evaluate the diagnostic and follow-up utility of urinary transforming growth factor beta(1) (TGF-beta(1)) and epidermal growth factor (EGF) in pediatric PUJO.
  • To assess the potential of these biomarkers in voided urine for children with PUJO.

Main Methods:

  • The study included 35 children with unilateral PUJO undergoing pyeloplasty and 30 healthy controls.
  • Urinary TGF-beta(1) and EGF levels were measured in pre-operative bladder samples and serial voided samples post-surgery.
  • Statistical analysis was performed to determine sensitivity, specificity, and predictive values.

Main Results:

  • Urinary TGF-beta(1) levels were significantly higher in PUJO patients pre-surgery compared to controls.
  • A TGF-beta(1) threshold of 190 pg/mg creatinine demonstrated high diagnostic accuracy (90.8%).
  • Urinary TGF-beta(1) levels decreased significantly one year post-pyeloplasty, while EGF showed no significant diagnostic or follow-up value.

Conclusions:

  • Urinary TGF-beta(1) is a valuable noninvasive biomarker for the long-term follow-up of pediatric PUJO after pyeloplasty.
  • Epidermal growth factor (EGF) is not recommended for routine diagnosis or follow-up of hydronephrosis in children.
  • Further research is needed to confirm the diagnostic accuracy of TGF-beta(1) in pediatric PUJO.
Abstract

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